5-Fluoro-2-methoxyphenylboronic acid

5-Fluoro-2-methoxyphenylboronic acid - Names and Identifiers

Name	5-Fluoro-2-methoxyphenylboronic acid
Synonyms	AKOS BRN-0214 CHEMBRDG-BB 4202998 RARECHEM AH PB 0134 5-FLUORO-2-METHOXYPHENYLBORONIC ACID 5-Fluoro-2-methoxyphenylboronic acid 2-METHOXY-5-FLUOROPHENYLBORONIC ACID 5-FLUORO-2-METHOXYBENZENEBORONIC ACID 5-fluoro-2-methoxybenzeneboronic acid 3-FLUORO-6-METHOXYBENZENEBORONIC ACID 2-Methoxy-5-Fluorobenzeneboronic Acid 2-METHOXY-5-FLUOROBENZENEBORONIC ACID (5-fluoro-2-hydroxyphenyl)boronic acid (5-Fluoro-2-methoxyphenyl)boronic acid
CAS	179897-94-0
InChI	InChI=1/C6H6BFO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9-11H

5-Fluoro-2-methoxyphenylboronic acid - Physico-chemical Properties

Molecular Formula	C7H8BFO3
Molar Mass	169.95
Density	1.26±0.1 g/cm3(Predicted)
Melting Point	144-153 °C (lit.)
Boling Point	337.1±52.0 °C(Predicted)
Flash Point	163.7°C
Vapor Presure	2.08E-05mmHg at 25°C
Appearance	Crystallization
Color	White
pKa	7.52±0.58(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.552
MDL	MFCD01863526

5-Fluoro-2-methoxyphenylboronic acid - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
HS Code	29163990
Hazard Class	IRRITANT

5-Fluoro-2-methoxyphenylboronic acid - Reference Information

Application

can be used as an intermediate for a new drug of selective non-steroidal small molecule hormone receptor antagonist, which has a non-steroidal structure Therefore, the side effects of using non-selective progesterone receptor antagonist drugs such as mifepristone on the human body can be avoided.

Preparation

About the synthesis of 5-fluoro-2-methoxyphenylboronic acid There are two main methods: 1) The reaction of p-fluoroanisole and the n-butyl lithium solution dissolved in THF at -60
℃ is protected by nitrogen, and then reacted with triisopropyl borate at -70 ℃ and then acidified with hydrochloric acid; 2) React with 2-bromo-4-fluoroanisole and the n-butyl lithium solution dissolved in THF
at -78 ℃, then react with trimethyl borate at room temperature, then acidify with hydrochloric acid, and wash with ammonium chloride solution.

Last Update：2024-04-10 22:29:15